Shuen-Iu Hung Selected Research

Drug Hypersensitivity Syndrome

1/2021	Granulysin-Based Lymphocyte Activation Test for Evaluating Drug Causality in Antiepileptics-Induced Severe Cutaneous Adverse Reactions.
1/2021	Whole genome sequencing identifies genetic variants associated with co-trimoxazole hypersensitivity in Asians.
1/2021	The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity.
1/2019	Increased Type 2 Innate Lymphoid Cells in Patients with Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome.
1/2018	The Function of HLA-B*13:01 Involved in the Pathomechanism of Dapsone-Induced Severe Cutaneous Adverse Reactions.
1/2016	Impact of the HLA-B(*)58:01 Allele and Renal Impairment on Allopurinol-Induced Cutaneous Adverse Reactions.
9/2015	Oxypurinol-Specific T Cells Possess Preferential TCR Clonotypes and Express Granulysin in Allopurinol-Induced Severe Cutaneous Adverse Reactions.
3/2005	HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.

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Shuen-Iu Hung Research Topics

Disease

33	Stevens-Johnson Syndrome (Lyell's Syndrome) 01/2021 - 04/2004
16	Hypersensitivity (Allergy) 05/2022 - 01/2002
13	Cicatrix (Scar) 01/2021 - 03/2005
12	Exanthema (Rash) 01/2021 - 02/2014
11	Drug Hypersensitivity (Drug Allergy) 01/2022 - 08/2007
8	Genetic Predisposition to Disease (Genetic Predisposition) 01/2021 - 03/2005
8	Drug Hypersensitivity Syndrome 01/2021 - 03/2005
8	Eosinophilia 01/2020 - 02/2014
7	Drug-Related Side Effects and Adverse Reactions 01/2021 - 08/2005
6	Neoplasms (Cancer) 04/2022 - 09/2011
5	Inflammation (Inflammations) 01/2019 - 07/2002
5	Blister (Bulla) 01/2018 - 12/2008
5	Schizophrenia (Dementia Praecox) 11/2008 - 11/2005
4	Necrosis 08/2017 - 12/2010
4	Gout 01/2017 - 03/2005
4	Hyperuricemia 01/2016 - 03/2005
3	Acute Liver Failure (Fulminant Hepatic Failure) 01/2015 - 01/2011
2	Infections 01/2021 - 05/2014
2	Epilepsy (Aura) 08/2020 - 04/2013
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 09/2015
2	Wounds and Injuries (Trauma) 01/2019 - 11/2014
2	Gouty Arthritis 01/2019 - 01/2017
2	Acute Generalized Exanthematous Pustulosis 05/2014 - 09/2010
1	Immediate Hypersensitivity 05/2022
1	Atopic Dermatitis (Atopic Eczema) 11/2021
1	Disseminated Intravascular Coagulation 06/2021
1	Drug Eruptions (Drug Eruption) 01/2021
1	Pneumonia (Pneumonitis) 01/2021
1	Adult-Onset Still's Disease 01/2020
1	Autoimmune Diseases (Autoimmune Disease) 10/2019
1	Cholangiocarcinoma 01/2019
1	Alopecia (Baldness) 01/2019
1	Osteoarthritis 01/2019
1	Erythema 01/2019

Drug/Important Bio-Agent (IBA)

30	Pharmaceutical PreparationsIBA 01/2021 - 04/2004
19	HLA-B Antigens (HLA-B)IBA 01/2021 - 04/2004
13	Carbamazepine (Tegretol)FDA LinkGeneric 01/2020 - 04/2004
9	HLA Antigens (Human Leukocyte Antigens)IBA 01/2022 - 04/2004
9	Allopurinol (Remid)FDA LinkGeneric 01/2020 - 03/2005
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2002
7	Anticonvulsants (Antiepileptic Drugs)IBA 01/2021 - 04/2006
6	Peptides (Polypeptides)IBA 04/2022 - 03/2005
4	AntigensIBA 04/2022 - 09/2013
4	Biomarkers (Surrogate Marker)IBA 01/2019 - 12/2011
4	Genetic Markers (Genetic Marker)IBA 11/2016 - 04/2004
3	VaccinesIBA 05/2022 - 01/2018
3	DNA (Deoxyribonucleic Acid)IBA 04/2022 - 12/2013
3	CytokinesIBA 01/2022 - 09/2013
3	ChemokinesIBA 01/2022 - 09/2013
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 03/2010
3	Phenytoin (Dilantin)FDA LinkGeneric 08/2020 - 08/2014
3	EnzymesIBA 01/2020 - 11/2016
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2019 - 12/2011
2	Immunoglobulin E (IgE)IBA 05/2022 - 11/2021
2	Immune Checkpoint InhibitorsIBA 01/2021 - 10/2019
2	Cytochrome P-450 CYP2C9IBA 08/2020 - 01/2019
2	HLA-B57 antigenIBA 01/2020 - 11/2019
2	HLA-A31 antigenIBA 01/2020 - 02/2014
2	abacavir (Ziagen)FDA Link 01/2020 - 08/2007
2	Febuxostat FDA Link 01/2019 - 09/2015
2	Uric Acid (Urate)IBA 01/2019 - 01/2017
2	Oxypurinol (Oxipurinol)IBA 12/2015 - 09/2015
2	Sodium Chloride Symporter Inhibitors (Diuretics, Thiazide)IBA 08/2015 - 08/2014
2	perforin-granzyme BIBA 06/2012 - 12/2008
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 05/2022
1	Excipients (Suspending Agents)IBA 05/2022
1	COVID-19 VaccinesIBA 05/2022
1	anti-IgE antibodiesIBA 05/2022
1	Polysorbates (PSML)FDA Link 05/2022
1	Messenger RNA (mRNA)IBA 04/2022
1	2-Propanol (Isopropyl Alcohol)FDA LinkGeneric 11/2021
1	dimethylamine (dimethylamine nitrate)IBA 11/2021
1	Filaggrin ProteinsIBA 11/2021
1	ProcalcitoninIBA 06/2021
1	SulfonamidesIBA 01/2021
1	Granzymes (Granzyme)IBA 01/2021
1	micaIBA 01/2021
1	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 01/2021
1	Macrophage Colony-Stimulating FactorIBA 01/2020
1	diacereinIBA 01/2019
1	Interleukin-5 (Interleukin 5)IBA 01/2019
1	Alanine Transaminase (SGPT)IBA 01/2019
1	Peptide Hydrolases (Proteases)FDA Link 01/2019
1	SteroidsIBA 01/2019
1	InterferonsIBA 01/2019
1	Interleukin-1 (Interleukin 1)IBA 01/2019
1	rheinIBA 01/2019
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019
1	AnthraquinonesIBA 01/2019
1	Conditioned Culture MediaIBA 01/2019
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2019
1	InflammasomesIBA 01/2019
1	Erythropoietin FDA Link 01/2019
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018
1	Etanercept (Enbrel)FDA Link 01/2018

Therapy/Procedure

4	Therapeutics 10/2019 - 03/2010
3	Immunotherapy 04/2022 - 01/2018
2	Oral Administration 01/2019 - 11/2014
2	Transplantation 09/2011 - 01/2011
1	Radiotherapy 01/2018